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FTY720 Normalizes Hyperglycemia by Stimulating β-Cell in Vivo Regeneration in db/db Mice through Regulation of Cyclin D3 and p57(KIP2)
Loss of insulin-producing β-cell mass is a hallmark of type 2 diabetes in humans and diabetic db/db mice. Pancreatic β-cells can modulate their mass in response to a variety of physiological and pathophysiological cues. There are currently few effective therapeutic approaches targeting β-cell regene...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3285331/ https://ncbi.nlm.nih.gov/pubmed/22194608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.305359 |
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