Sequential immunization with heterologous chimeric flavivirus induces broad-spectrum cross-reactive CD8(+) T-cell responses

Flavivirus vaccines based upon the ChimeriVax™ technology contain the nonstructural genes of the yellow fever (YF) vaccine and the prM and E genes of heterologous flaviviruses such as Japanese encephalitis (JE) and West Nile (WN) viruses. These chimeric vaccines induce both humoral and cell mediated...

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Main Authors: Singh, Rekha, Rothman, Alan L., Potts, James, Guirakhoo, Farshad, Ennis, Francis A., Green, Sharone
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903744/
https://ncbi.nlm.nih.gov/pubmed/20536361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/653486
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