REACTIVE γ-KETOALDEHYDES FORMED VIA THE ISOPROSTANE PATHWAY DISRUPT MITOCHONDRIAL RESPIRATION AND CALCIUM HOMEOSTASIS

Isoketals (IsoKs) are γ-ketoaldehydes formed via the isoprostane pathway of arachidonic acid peroxidation and are among the most reactive byproducts of lipid peroxidation. IsoKs selectively adduct to protein lysine residues and are highly cytotoxic, but the targets and molecular events involved in I...

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Detalhes bibliográficos
Main Authors: Stavrovskaya, Irina G., Baranov, Sergei V., Guo, Xiaofeng, Davies, Sean S., Roberts, L. Jackson, Kristal, Bruce S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903647/
https://ncbi.nlm.nih.gov/pubmed/20472054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.04.037
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