Computational design of a PAK1 binding protein

We describe a computational protocol, called DDMI, for redesigning scaffold proteins to bind to a specified region on a target protein. The DDMI protocol is implemented within the Rosetta molecular modeling program and uses rigid-body docking, sequence design, and gradient-based minimization of back...

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Bibliografiske detaljer
Main Authors: Jha, Ramesh K., Leaver-Fay, Andrew, Yin, Shuangye, Wu, Yibing, Butterfoss, Glenn L., Szyperski, Thomas, Dokholyan, Nikolay V., Kuhlman, Brian
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903434/
https://ncbi.nlm.nih.gov/pubmed/20460129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.05.006
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