Parallel in Vivo and in Vitro Selection Using Phage Display Identifies Protease-dependent Tumor-targeting Peptides

We recently developed activatable cell-penetrating peptides (ACPPs) that target contrast agents to in vivo sites of matrix metalloproteinase activity, such as tumors. Here we use parallel in vivo and in vitro selection with phage display to identify novel tumor-homing ACPPs with no bias for primary...

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Autors principals: Whitney, Mike, Crisp, Jessica L., Olson, Emilia S., Aguilera, Todd A., Gross, Larry A., Ellies, Lesley G., Tsien, Roger Y.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903386/
https://ncbi.nlm.nih.gov/pubmed/20460372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.138297
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