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In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer

Activatable cell penetrating peptides (ACPPs) are novel in vivo targeting agents comprised of a polycationic cell penetrating peptide (CPP) connected via a cleavable linker to a neutralizing polyanion (Fig. 1A). Adsorption and uptake into cells are inhibited until the linker is proteolyzed1–3. An AC...

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Detalhes bibliográficos
Main Authors: Olson, Emilia S., Aguilera, Todd A., Jiang, Tao, Ellies, Lesley G., Nguyen, Quyen T., Wong, Edmund, Gross, Larry, Tsien, Roger Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796841/
https://ncbi.nlm.nih.gov/pubmed/20023745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b904890a
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