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Thy-1-Integrin α(v)β(5) Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation

Myofibroblasts, key effector cells in tissue fibrosis, are specialized contractile cells. Lung myofibroblast contraction induces integrin α(v)β(5)-dependent latent transforming growth factor (TGF)-β1 activation suggests that myofibroblast contractility may be a driving force for the persistent myofi...

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Main Authors: Zhou, Yong, Hagood, James S., Lu, Baogen, Merryman, W. David, Murphy-Ullrich, Joanne E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903374/
https://ncbi.nlm.nih.gov/pubmed/20463011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126227
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