Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

Ras family small GTPases assume two interconverting conformations, “inactive” state 1 and “active” state 2, in their GTP-bound forms. Here, to clarify the mechanism of state transition, we have carried out x-ray crystal structure analyses of a series of mutant H-Ras and M-Ras in complex with guanosi...

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Detalles Bibliográficos
Autores principales: Shima, Fumi, Ijiri, Yuichi, Muraoka, Shin, Liao, Jingling, Ye, Min, Araki, Mitsugu, Matsumoto, Kousuke, Yamamoto, Naoki, Sugimoto, Takeshi, Yoshikawa, Yoko, Kumasaka, Takashi, Yamamoto, Masaki, Tamura, Atsuo, Kataoka, Tohru
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903345/
https://ncbi.nlm.nih.gov/pubmed/20479006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.125161
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