Lack of Efficacy of Bevacizumab Plus Irinotecan in Children With Recurrent Malignant Glioma and Diffuse Brainstem Glioma: A Pediatric Brain Tumor Consortium Study

PURPOSE: A phase II study of bevacizumab (BVZ) plus irinotecan (CPT-11) was conducted in children with recurrent malignant glioma (MG) and intrinsic brainstem glioma (BSG). PATIENTS AND METHODS: Eligible patients received two doses of BVZ intravenously (10 mg/kg) 2 weeks apart and then BVZ plus CPT-...

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Bibliographic Details
Main Authors: Gururangan, Sridharan, Chi, Susan N., Young Poussaint, Tina, Onar-Thomas, Arzu, Gilbertson, Richard J., Vajapeyam, Sridhar, Friedman, Henry S., Packer, Roger J., Rood, Brian N., Boyett, James M., Kun, Larry E.
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2010
Subjects:
Original Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903337/
https://ncbi.nlm.nih.gov/pubmed/20479404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.26.8789
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