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Clinical Relevance of Microsatellite Instability in Colorectal Cancer
Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide units in microsatellites. It arises in tumors with deficient mismatch repair due to the inactivation of one of the four mismatch repair genes: MSH2, MLH1, MSH6, and PMS2. In order to determine the MSI status...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Clinical Oncology
2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903331/ https://ncbi.nlm.nih.gov/pubmed/20516444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.27.0652 |
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