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Clinical Relevance of Microsatellite Instability in Colorectal Cancer

Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide units in microsatellites. It arises in tumors with deficient mismatch repair due to the inactivation of one of the four mismatch repair genes: MSH2, MLH1, MSH6, and PMS2. In order to determine the MSI status...

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Hlavní autoři: de la Chapelle, Albert, Hampel, Heather
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903331/
https://ncbi.nlm.nih.gov/pubmed/20516444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.27.0652
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