Bortezomib-induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 MAPK pathway

Esophageal squamous cell carcinoma (ESCC) is an exceptionally drug resistant tumor with a five-year survival rate <5%. From an initial drug screen we identified bortezomib as having robust activity in ESCC lines. Mechanistically, bortezomib induced a G2/M phase cell cycle arrest and p53-independe...

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Detalhes bibliográficos
Main Authors: Lioni, Mercedes, Noma, Kazuhiro, Snyder, Andrew, Klein-Szanto, Andres, Diehl, J. Alan, Rustgi, Anil K., Herlyn, Meenhard, Smalley, Keiran S M
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903039/
https://ncbi.nlm.nih.gov/pubmed/18790767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0391
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