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IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the Phosphoinositide 3-kinase (PI3-K)/Akt pathway
Understanding the factors that regulate sebum production is important in identifying novel therapeutic targets for acne therapy. Insulin and insulin-like growth factor-1 (IGF-1) stimulate sebaceous gland lipogenesis. IGF-1 increases expression of sterol response element binding protein-1 (SREBP-1),...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902866/ https://ncbi.nlm.nih.gov/pubmed/17989724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.jid.5701155 |
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