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Synthesis of an Fmoc-threonine bearing core-2 glycan: A building block for PSGL-1 via Fmoc-assisted solid-phase peptide synthesis

Selectins (L, E- and P) are vascular endothelial molecules that play an important role in the recruitment of leukocytes to inflamed tissue. In this regard, P-Selectin glycoprotein-1 (PSGL-1) has been identified as a ligand for P-Selectin. PSGL-1 binds to P-Selectin through the interaction of core-2...

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Autores principales: Krishnamurthy, Venkata R, Dougherty, Ann, Kamath, Medha, Song, Xuezheng, Cummings, Richard D., Chaikof, Elliot. L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902660/
https://ncbi.nlm.nih.gov/pubmed/20561607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carres.2010.05.004
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