Glycopeptide Analogues of PSGL-1 Inhibit P-Selectin In Vitro and In Vivo

Blockade of P-selectin/PSGL-1 interactions holds significant potential for treatment of disorders of innate immunity, thrombosis, and cancer. Current inhibitors remain limited due to low binding affinity or by the recognized disadvantages inherent to chronic administration of antibody therapeutics....

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Krishnamurthy, Venkata R, Sardar, Mohammed Y. R., Yu, Ying, Song, Xuezheng, Haller, Carolyn, Dai, Erbin, Wang, Xiacong, Hanjaya-Putra, Donny, Sun, Lijun, Morikis, Vasilios, Simon, Scott I., Woods, Robert, Cummings, Richard D., Chaikof, Elliot L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423566/
https://ncbi.nlm.nih.gov/pubmed/25824568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7387
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