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Elevated IL-17 produced by T(h)17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma
Elevated cytokines in bone marrow (BM) micro-environment (interleukin-6 [IL-6], transforming growth factor-beta [TGF-β], and IL-1β) may play an important role in observed immune dysfunction in multiple myeloma (MM). As IL-6 and TGF-β are important for the generation of T-helper 17 (T(H)17) cells, we...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902136/ https://ncbi.nlm.nih.gov/pubmed/20395418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-246660 |
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