Elevated IL-17 produced by T(h)17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma

Elevated cytokines in bone marrow (BM) micro-environment (interleukin-6 [IL-6], transforming growth factor-beta [TGF-β], and IL-1β) may play an important role in observed immune dysfunction in multiple myeloma (MM). As IL-6 and TGF-β are important for the generation of T-helper 17 (T(H)17) cells, we...

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Main Authors: Prabhala, Rao H., Pelluru, Dheeraj, Fulciniti, Mariateresa, Prabhala, Harsha K., Nanjappa, Puru, Song, Weihua, Pai, Christine, Amin, Samir, Tai, Yu-Tzu, Richardson, Paul G., Ghobrial, Irene M., Treon, Steven P., Daley, John F., Anderson, Kenneth C., Kutok, Jeffery L., Munshi, Nikhil C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902136/
https://ncbi.nlm.nih.gov/pubmed/20395418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-246660
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