TAC3/TACR3 Mutations Reveal Preferential Activation of Gonadotropin-Releasing Hormone Release by Neurokinin B in Neonatal Life Followed by Reversal in Adulthood

Context: Mutations in TAC3 and TACR3 (encoding neurokinin B and its receptor) have been identified in Turkish patients with idiopathic hypogonadotropic hypogonadism (IHH), but broader populations have not yet been tested and genotype-phenotype correlations have not been established. Objective: A bro...

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Main Authors: Gianetti, Elena, Tusset, Cintia, Noel, Sekoni D., Au, Margaret G., Dwyer, Andrew A., Hughes, Virginia A., Abreu, Ana Paula, Carroll, Jessica, Trarbach, Ericka, Silveira, Leticia F. G., Costa, Elaine M. F., de Mendonça, Berenice Bilharinho, de Castro, Margaret, Lofrano, Adriana, Hall, Janet E., Bolu, Erol, Ozata, Metin, Quinton, Richard, Amory, John K., Stewart, Susan E., Arlt, Wiebke, Cole, Trevor R., Crowley, William F., Kaiser, Ursula B., Latronico, Ana Claudia, Seminara, Stephanie B.
格式: Artigo
語言:Inglês
出版: The Endocrine Society 2010
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902066/
https://ncbi.nlm.nih.gov/pubmed/20332248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2009-2320
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