Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene

BACKGROUND: Substance P (SP) is a pain- and inflammation-related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK(1)). SP and NK(1) receptors have been implicated in joint pain, inflammation and damage in animal models and human studies of osteoarthritis (OA). The aim of this...

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Bibliographic Details
Published in:Eur J Pain
Main Authors: Warner, Sophie C, Walsh, David A, Laslett, Laura L, Maciewicz, Rose A, Soni, Anushka, Hart, Deborah J, Zhang, Weiya, Muir, Kenneth R, Dennison, Elaine M, Leaverton, Paul, Rampersaud, Evadnie, Cooper, Cyrus, Spector, Tim D, Cicuttini, Flavia M, Arden, Nigel K, Jones, Graeme, Doherty, Michael, Valdes, Ana M
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511507/
https://ncbi.nlm.nih.gov/pubmed/28493529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejp.1027
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