Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene

BACKGROUND: Substance P (SP) is a pain- and inflammation-related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK(1)). SP and NK(1) receptors have been implicated in joint pain, inflammation and damage in animal models and human studies of osteoarthritis (OA). The aim of this...

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Detalhes bibliográficos
Publicado no:Eur J Pain
Main Authors: Warner, Sophie C, Walsh, David A, Laslett, Laura L, Maciewicz, Rose A, Soni, Anushka, Hart, Deborah J, Zhang, Weiya, Muir, Kenneth R, Dennison, Elaine M, Leaverton, Paul, Rampersaud, Evadnie, Cooper, Cyrus, Spector, Tim D, Cicuttini, Flavia M, Arden, Nigel K, Jones, Graeme, Doherty, Michael, Valdes, Ana M
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511507/
https://ncbi.nlm.nih.gov/pubmed/28493529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejp.1027
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