TAC3 and TACR3 Mutations in Familial Hypogonadotropic Hypogonadism Reveal a Key Role for Neurokinin B in the Central Control of Reproduction

The timely secretion of gonadal sex steroids is essential for the initiation of puberty, the post-pubertal maintenance of secondary sexual characteristics and the normal perinatal development of male external genitalia. Normal gonadal steroid production requires the actions of the pituitary-derived...

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Udgivet i:Nat Genet
Main Authors: Topaloglu, A.Kemal, Reimann, Frank, Guclu, Metin, Yalin, Ayse Serap, Kotan, L. Damla, Porter, Keith M, Serin, Ayse, Mungan, Neslihan O, Cook, Joshua R, Imamoglu, Sazi, Akalin, N. Sema, Yuksel, Bilgin, O’Rahilly, Stephen, Semple, Robert K
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312696/
https://ncbi.nlm.nih.gov/pubmed/19079066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.306
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