TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients

Neurokinin B (NKB) and its G-protein-coupled receptor, NK3R, have been implicated in the neuroendocrine control of GnRH release; however, little is known about the structure-function relationship of this ligand-receptor pair. Moreover, loss-of-function NK3R mutations cause GnRH deficiency in humans....

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Bibliographic Details
Main Authors: Noel, Sekoni D., Abreu, Ana Paula, Xu, Shuyun, Muyide, Titilayo, Gianetti, Elena, Tusset, Cintia, Carroll, Jessica, Latronico, Ana Claudia, Seminara, Stephanie B., Carroll, Rona S., Kaiser, Ursula B.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2014
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963009/
https://ncbi.nlm.nih.gov/pubmed/24376026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-240630
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