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GnRH Pulse Frequency-Dependent Stimulation of FSHβ Transcription Is Mediated via Activation of PKA and CREB

Expression of pituitary FSH and LH, under the control of pulsatile GnRH, is essential for fertility. cAMP response element-binding protein (CREB) has been implicated in the regulation of FSHβ gene expression, but the molecular mechanisms by which pulsatile GnRH regulates CREB activation remain poorl...

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Detalhes bibliográficos
Main Authors: Thompson, Iain R., Ciccone, Nick A., Xu, Shuyun, Zaytseva, Sofiya, Carroll, Rona S., Kaiser, Ursula B.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607701/
https://ncbi.nlm.nih.gov/pubmed/23393127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1281
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