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GnRH Pulse Frequency-Dependent Stimulation of FSHβ Transcription Is Mediated via Activation of PKA and CREB

Expression of pituitary FSH and LH, under the control of pulsatile GnRH, is essential for fertility. cAMP response element-binding protein (CREB) has been implicated in the regulation of FSHβ gene expression, but the molecular mechanisms by which pulsatile GnRH regulates CREB activation remain poorl...

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Hlavní autoři: Thompson, Iain R., Ciccone, Nick A., Xu, Shuyun, Zaytseva, Sofiya, Carroll, Rona S., Kaiser, Ursula B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607701/
https://ncbi.nlm.nih.gov/pubmed/23393127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1281
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