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Strategies for Extracting Structural Information from 2D IR Spectroscopy of Amyloid: Application to Islet Amyloid Polypeptide

The 37-residue human islet amyloid polypeptide (hIAPP or amylin) self-assembles into fibers, the assembly of which has been associated with the disease mechanism of type II diabetes. Infrared spectroscopy in conjunction with isotope labeling is proving to be a powerful tool for studying the aggregat...

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Detalhes bibliográficos
Main Authors: Strasfeld, David B., Ling, Yun L., Gupta, Ruchi, Raleigh, Daniel P., Zanni, Martin T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901919/
https://ncbi.nlm.nih.gov/pubmed/19883093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp9072203
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