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Two-dimensional IR spectroscopy and isotope labeling defines the pathway of amyloid formation with residue-specific resolution

There is considerable interest in uncovering the pathway of amyloid formation because the toxic properties of amyloid likely stems from prefibril intermediates and not the fully formed fibrils. Using a recently invented method of collecting 2-dimensional infrared spectra and site-specific isotope la...

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Bibliographic Details
Main Authors: Shim, Sang-Hee, Gupta, Ruchi, Ling, Yun L., Strasfeld, David B., Raleigh, Daniel P., Zanni, Martin T.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672516/
https://ncbi.nlm.nih.gov/pubmed/19346479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805957106
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