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Two-dimensional IR spectroscopy and isotope labeling defines the pathway of amyloid formation with residue-specific resolution

There is considerable interest in uncovering the pathway of amyloid formation because the toxic properties of amyloid likely stems from prefibril intermediates and not the fully formed fibrils. Using a recently invented method of collecting 2-dimensional infrared spectra and site-specific isotope la...

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Библиографические подробности
Главные авторы: Shim, Sang-Hee, Gupta, Ruchi, Ling, Yun L., Strasfeld, David B., Raleigh, Daniel P., Zanni, Martin T.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672516/
https://ncbi.nlm.nih.gov/pubmed/19346479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805957106
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