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2D IR Provides Evidence of an Intermediate in the Membrane-catalyzed Assembly of Diabetic Amyloid

Islet amyloid polypeptide (IAPP, also known as amylin) is responsible for pancreatic amyloid deposits in type 2 diabetes. The deposits, as well as intermediates in their assembly, are cytotoxic to pancreatic β-cells and contribute to the loss of β-cell mass associated with type 2 diabetes. The facto...

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Detalhes bibliográficos
Main Authors: Ling, Yun L., Strasfeld, David B., Shim, Sang-Hee, Raleigh, Daniel P., Zanni, Martin T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692222/
https://ncbi.nlm.nih.gov/pubmed/19182939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp810261x
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