Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

Activation of the cellular DNA damage response is detrimental to adenovirus (Ad) infection. Ad has therefore evolved a number of strategies to inhibit ATM- and ATR-dependent signaling pathways during infection. Recent work suggests that the Ad5 E4orf3 protein prevents ATR activation through its abil...

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Autors principals: Blackford, Andrew N., Patel, Rakesh N., Forrester, Natalie A., Theil, Kathrin, Groitl, Peter, Stewart, Grant S., Taylor, A. Malcolm R., Morgan, Iain M., Dobner, Thomas, Grand, Roger J. A., Turnell, Andrew S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901489/
https://ncbi.nlm.nih.gov/pubmed/20566845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914605107
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