Imaging tuberculosis with endogenous β-lactamase reporter enzyme fluorescence in live mice

The slow growth rate and genetic intractability of tubercle bacilli has hindered progress toward understanding tuberculosis, one of the most frequent causes of death worldwide. We overcame this roadblock through development of near-infrared (NIR) fluorogenic substrates for β-lactamase, an enzyme exp...

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Main Authors: Kong, Ying, Yao, Hequan, Ren, Hongjun, Subbian, Selvakumar, Cirillo, Suat L. G., Sacchettini, James C., Rao, Jianghong, Cirillo, Jeffrey D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901431/
https://ncbi.nlm.nih.gov/pubmed/20566877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000643107
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