Imaging tuberculosis with endogenous β-lactamase reporter enzyme fluorescence in live mice

The slow growth rate and genetic intractability of tubercle bacilli has hindered progress toward understanding tuberculosis, one of the most frequent causes of death worldwide. We overcame this roadblock through development of near-infrared (NIR) fluorogenic substrates for β-lactamase, an enzyme exp...

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Библиографические подробности
Главные авторы: Kong, Ying, Yao, Hequan, Ren, Hongjun, Subbian, Selvakumar, Cirillo, Suat L. G., Sacchettini, James C., Rao, Jianghong, Cirillo, Jeffrey D.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901431/
https://ncbi.nlm.nih.gov/pubmed/20566877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000643107
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