Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration

Frontotemporal lobar degeneration is a fatal neurodegenerative disease that results in progressive decline in behavior, executive function and sometimes language. Disease mechanisms remain poorly understood. Recently, however, the DNA- and RNA-binding protein TDP-43 has been identified as the major...

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Main Authors: Chen-Plotkin, Alice S., Geser, Felix, Plotkin, Joshua B., Clark, Chris M., Kwong, Linda K., Yuan, Wuxing, Grossman, Murray, Van Deerlin, Vivianna M., Trojanowski, John Q., Lee, Virginia M.-Y.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900863/
https://ncbi.nlm.nih.gov/pubmed/18223198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn023
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