Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

Recombinant proteins are important therapeutics due to potent, highly specific, and nontoxic actions in vivo. However, they are expensive medicines to manufacture, chemically unstable, and difficult to administer with low patient uptake and compliance. Small molecule drugs are cheaper and more bioav...

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Detaylı Bibliyografya
Asıl Yazarlar: Harrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Ruiz-Gómez, Gloria, Hill, Timothy A., Driver, Russell W., Desai, Vishal S., Young, Paul R., Abbenante, Giovanni, Fairlie, David P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2010
Konular:
Physical Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900680/
https://ncbi.nlm.nih.gov/pubmed/20543141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002498107
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