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Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency
Recombinant proteins are important therapeutics due to potent, highly specific, and nontoxic actions in vivo. However, they are expensive medicines to manufacture, chemically unstable, and difficult to administer with low patient uptake and compliance. Small molecule drugs are cheaper and more bioav...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900680/ https://ncbi.nlm.nih.gov/pubmed/20543141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002498107 |
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