Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

Recombinant proteins are important therapeutics due to potent, highly specific, and nontoxic actions in vivo. However, they are expensive medicines to manufacture, chemically unstable, and difficult to administer with low patient uptake and compliance. Small molecule drugs are cheaper and more bioav...

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Bibliografiske detaljer
Main Authors: Harrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Ruiz-Gómez, Gloria, Hill, Timothy A., Driver, Russell W., Desai, Vishal S., Young, Paul R., Abbenante, Giovanni, Fairlie, David P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900680/
https://ncbi.nlm.nih.gov/pubmed/20543141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002498107
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