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Salicylate-urea based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities
We investigated N-adamantyl-N′-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and...
Tallennettuna:
| Päätekijät: | , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900318/ https://ncbi.nlm.nih.gov/pubmed/19216074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.01.069 |
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