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Auto-inhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity

Nck is a functionally versatile multidomain adaptor protein consisting of one SH2 and three SH3 domains. In most cases, the SH2 domain mediates binding to tyrosine-phosphorylated receptors or cytosolic proteins, which leads to the formation of larger protein complexes via the SH3 domains. Nck plays...

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Библиографические подробности
Главные авторы: Takeuchi, Koh, Sun, Zhen-Yu J., Park, Sunghyouk, Wagner, Gerhard
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2899887/
https://ncbi.nlm.nih.gov/pubmed/20527928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100322m
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