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Auto-inhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity
Nck is a functionally versatile multidomain adaptor protein consisting of one SH2 and three SH3 domains. In most cases, the SH2 domain mediates binding to tyrosine-phosphorylated receptors or cytosolic proteins, which leads to the formation of larger protein complexes via the SH3 domains. Nck plays...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2899887/ https://ncbi.nlm.nih.gov/pubmed/20527928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100322m |
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