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Structural and functional evidence that Nck interaction with CD3ε regulates T cell receptor activity
Recruitment of signaling molecules to the cytoplasmic domains of the CD3 subunits of the T cell receptor (TCR) is crucial for early T cell activation. These transient associations either do or do not require tyrosine phosphorylation of CD3 immune tyrosine activation motifs (ITAMs). Here we show that...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577852/ https://ncbi.nlm.nih.gov/pubmed/18555270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.037 |
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