Mapping of the Auto-Inhibitory Interactions of Protein Kinase R by Nuclear Magnetic Resonance

The dsRNA-dependent protein kinase (PKR) is a key mediator of the anti-viral and anti-proliferative effects of interferon. Unphosphorylated PKR is characterized by inhibitory interactions between the kinase and RNA binding domains (RBDs), but the structural details of the latent state and its unrave...

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Bibliografiset tiedot
Päätekijät: Gelev, Vladimir, Aktas, Husseyin, Marintchev, Assen, Ito, Takuhiro, Frueh, Dominique, Hemond, Michael, Rovnyak, David, Debus, Miriam, Hyberts, Sven, Usheva, Anny, Halperin, Jose, Wagner, Gerhard
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622519/
https://ncbi.nlm.nih.gov/pubmed/17011579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.08.077
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