Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion

BACKGROUND: Prohormone convertase 1 is involved in maturation of peptides. Rare mutations in gene PCSK1, encoding this enzyme, cause childhood obesity and abnormal glucose homeostasis with elevated proinsulin concentrations. Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and...

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Détails bibliographiques
Auteurs principaux: Heni, Martin, Haupt, Axel, Schäfer, Silke A, Ketterer, Caroline, Thamer, Claus, Machicao, Fausto, Stefan, Norbert, Staiger, Harald, Häring, Hans-Ulrich, Fritsche, Andreas
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898666/
https://ncbi.nlm.nih.gov/pubmed/20534142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-11-86
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