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Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion
BACKGROUND: Prohormone convertase 1 is involved in maturation of peptides. Rare mutations in gene PCSK1, encoding this enzyme, cause childhood obesity and abnormal glucose homeostasis with elevated proinsulin concentrations. Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898666/ https://ncbi.nlm.nih.gov/pubmed/20534142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-11-86 |
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