Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion

BACKGROUND: Prohormone convertase 1 is involved in maturation of peptides. Rare mutations in gene PCSK1, encoding this enzyme, cause childhood obesity and abnormal glucose homeostasis with elevated proinsulin concentrations. Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and...

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書誌詳細
主要な著者: Heni, Martin, Haupt, Axel, Schäfer, Silke A, Ketterer, Caroline, Thamer, Claus, Machicao, Fausto, Stefan, Norbert, Staiger, Harald, Häring, Hans-Ulrich, Fritsche, Andreas
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2010
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898666/
https://ncbi.nlm.nih.gov/pubmed/20534142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-11-86
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