Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein

Both sequence-specific DNA binding and exonuclease activities have been mapped to the central conserved core domain of p53. To gain more information about these two activities a series of mutants were generated that changed core domain histidine residues. Of these mutants, only one, H115N p53, showe...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Ahn, Jinwoo, Poyurovsky, Masha V., Baptiste, Nicole, Beckerman, Rachel, Cain, Christine, Mattia, Melissa, McKinney, Kristine, Zhou, Jianmin, Zupnick, Andrew, Gottifredi, Vanesa, Prives, Carol
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898518/
https://ncbi.nlm.nih.gov/pubmed/19462533
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker