Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein

Both sequence-specific DNA binding and exonuclease activities have been mapped to the central conserved core domain of p53. To gain more information about these two activities a series of mutants were generated that changed core domain histidine residues. Of these mutants, only one, H115N p53, showe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ahn, Jinwoo, Poyurovsky, Masha V., Baptiste, Nicole, Beckerman, Rachel, Cain, Christine, Mattia, Melissa, McKinney, Kristine, Zhou, Jianmin, Zupnick, Andrew, Gottifredi, Vanesa, Prives, Carol
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898518/
https://ncbi.nlm.nih.gov/pubmed/19462533
Tagiau: Ychwanegu Tag
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