Cdk1 Activity Is Required for Mitotic Activation of Aurora A during G(2)/M Transition of Human Cells

In mammalian cells entry into and progression through mitosis are regulated by multiple mitotic kinases. How mitotic kinases interact with each other and coordinately regulate mitosis remains to be fully understood. Here we employed a chemical biology approach using selective small molecule kinase i...

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Hauptverfasser: Van Horn, Robert D., Chu, Shaoyou, Fan, Li, Yin, Tinggui, Du, Jian, Beckmann, Richard, Mader, Mary, Zhu, Guoxin, Toth, John, Blanchard, Kerry, Ye, Xiang S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898447/
https://ncbi.nlm.nih.gov/pubmed/20444701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.141010
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