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Targeting the MAPK Pathway in Melanoma: Why some approaches succeed and other fail
The Mitogen Activated Protein Kinase (MAPK) pathway plays a key role in melanoma development making it an important therapeutic target. In normal cells, the tightly regulated pathway relays extracellular signals from cell membrane to nucleus via a cascade of phosphorylation events. In melanomas, dys...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2897908/ https://ncbi.nlm.nih.gov/pubmed/20450891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.04.029 |
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