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Targeting the MAPK Pathway in Melanoma: Why some approaches succeed and other fail

The Mitogen Activated Protein Kinase (MAPK) pathway plays a key role in melanoma development making it an important therapeutic target. In normal cells, the tightly regulated pathway relays extracellular signals from cell membrane to nucleus via a cascade of phosphorylation events. In melanomas, dys...

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Detalhes bibliográficos
Main Authors: Inamdar, Gajanan S, Madhunapantula, SubbaRao V., Robertson, Gavin P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897908/
https://ncbi.nlm.nih.gov/pubmed/20450891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.04.029
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