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The Akt signaling pathway: An emerging therapeutic target in malignant melanoma
Studies using cultured melanoma cells and patient tumor biopsies have demonstrated deregulated PI3 kinase-Akt3 pathway activity in ∼70% of melanomas. Furthermore, targeting Akt3 and downstream PRAS40 has been shown to inhibit melanoma tumor development in mice. Although these preclinical studies and...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3335938/ https://ncbi.nlm.nih.gov/pubmed/22157148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.12.18442 |
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