HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction

Endoplasmic reticulum (ER) stress is a feature of secretory cells and of many diseases including cancer, neurodegeneration, and diabetes. Adaptation to ER stress depends on the activation of a signal transduction pathway known as the unfolded protein response (UPR). Enhanced expression of Hsp72 has...

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Detalhes bibliográficos
Main Authors: Gupta, Sanjeev, Deepti, Ayswaria, Deegan, Shane, Lisbona, Fernanda, Hetz, Claudio, Samali, Afshin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897763/
https://ncbi.nlm.nih.gov/pubmed/20625543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000410
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