Glycosylation Steps during Spiramycin Biosynthesis in Streptomyces ambofaciens: Involvement of Three Glycosyltransferases and Their Interplay with Two Auxiliary Proteins

Streptomyces ambofaciens synthesizes spiramycin, a 16-membered macrolide antibiotic used in human medicine. The spiramycin molecule consists of a polyketide lactone ring (platenolide) synthesized by a type I polyketide synthase, to which three deoxyhexoses (mycaminose, forosamine, and mycarose) are...

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Autori principali: Nguyen, Hoang Chuong, Karray, Fatma, Lautru, Sylvie, Gagnat, Josette, Lebrihi, Ahmed, Ho Huynh, Thuy Duong, Pernodet, Jean-Luc
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Chemistry; Biosynthesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897285/
https://ncbi.nlm.nih.gov/pubmed/20439613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01602-09
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