Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis

Loss-of-function mutations in the NF1 tumor suppressor result in deregulated Ras signaling and drive tumorigenesis in the familial cancer syndrome neurofibromatosis type I. However, the extent to which NF1-inactivation promotes sporadic tumorigenesis is unknown. Here we report that NF1 is inactivate...

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Main Authors: McGillicuddy, Lauren T., Fromm, Jody A., Hollstein, Pablo E., Kubek, Sara, Beroukhim, Rameen, De Raedt, Thomas, Johnson, Bryan W., Williams, Sybil M.G., Nghiemphu, Phioanh, Liau, Linda, Cloughesy, Tim F., Mischel, Paul S., Parret, Annabel, Seiler, Jeanette, Moldenhauer, Gerd, Scheffzek, Klaus, Stemmer-Rachamimov, Anat O., Sawyers, Charles L., Brennan, Cameron, Messiaen, Ludwine, Mellinghoff, Ingo K., Cichowski, Karen
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897249/
https://ncbi.nlm.nih.gov/pubmed/19573811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.05.009
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