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Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis

The RNA-dependent RNA-polymerase, 3D(pol), is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of 3D(pol) in mice has antiviral effects. Here, we discuss the structure and function of 3D(pol) during picornavirus replication,...

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Autors principals: Kerkvliet, Jason, Edukulla, Ramakrishna, Rodriguez, Moses
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897181/
https://ncbi.nlm.nih.gov/pubmed/20625447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/368068
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