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A radical on the Met-Tyr-Trp modification required for catalase activity in catalase-peroxidase is established by isotopic labeling and site-directed mutagenesis
[Image: see text] A transient tyrosyl-like radical with a narrow doublet X-band EPR signal is present during catalase turnover by M. tuberculosis catalase-peroxidase (KatG). Labeling of KatG with β-methylene deuterated tyrosine causes a collapse of the doublet to a singlet, while for 3,5- ring-deute...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2897066/ https://ncbi.nlm.nih.gov/pubmed/20507091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja103311e |
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