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A mouse model of melanoma driven by oncogenic KRAS

The small G-protein NRAS is mutated in 22% of human melanomas, whereas the related proteins, KRAS and HRAS are mutated in only 2% and 1% of melanomas respectively. We have developed a mouse models of melanoma in which Cre recombinase/loxP technology is used to drive inducible expression of (G12V)KRA...

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Hlavní autoři: Milagre, Carla, Dhomen, Nathalie, Geyer, Felipe C, Hayward, Robert, Lambros, Maryou, Reis-Filho, Jorge S, Marais, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896549/
https://ncbi.nlm.nih.gov/pubmed/20516123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4254
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